Dual Targeting of CDK4/6 and cMET in Metastatic Uveal Melanoma
نویسندگان
چکیده
منابع مشابه
Long-Term Survivors with Metastatic Uveal Melanoma
BACKGROUND To report the tumor, patient, and treatment characteristics of long-term metastatic uveal melanoma survivors. METHODS A non-comparative, retrospective case series of patients from a single institution surviving >24 months with metastatic uveal melanoma (UM). RESULTS Nine patients met the study criteria and their charts were reviewed. The mean age at diagnosis of UM was 44.1 years...
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PURPOSE New medications and combination treatment strategies for patients with metastatic melanoma are discussed. SUMMARY Bcl-2 is an inhibitor of apoptosis that is overexpressed in approximately 80% of melanoma cell lines and is believed to contribute to the development of resistance to cytotoxic chemotherapy in patients with melanoma. Oblimersen, an antisense oligonucleotide that stops the ...
متن کاملSurvival in patients with presymptomatic diagnosis of metastatic uveal melanoma.
OBJECTIVE To determine if patients diagnosed as having metastatic uveal melanoma before the onset of symptoms experience more favorable survival outcomes than patients diagnosed after the onset of symptoms. METHODS A retrospective cohort study was performed among 90 patients who were diagnosed as having metastatic uveal melanoma after proton beam irradiation by routine surveillance testing (a...
متن کاملTissue-Based Microarray Expression of Genes Predictive of Metastasis in Uveal Melanoma and Differentially Expressed in Metastatic Uveal Melanoma
PURPOSE To screen the microarray expression of CDH1, ECM1, EIF1B, FXR1, HTR2B, ID2, LMCD1, LTA4H, MTUS1, RAB31, ROBO1, and SATB1 genes which are predictive of primary uveal melanoma metastasis, and NFKB2, PTPN18, MTSS1, GADD45B, SNCG, HHIP, IL12B, CDK4, RPLP0, RPS17, RPS12 genes that are differentially expressed in metastatic uveal melanoma in normal whole human blood and tissues prone to metas...
متن کاملMetastatic uveal melanoma: diagnosis and treatment. A literature review.
In the past three decades many efforts were done to improve the visual prognosis of patients with uveal melanoma. However, mortality has remained unchanged. The systemic prognosis depends on the size and other characteristics of the lesion. It is not affected by the choice of local treatment. This suggests dissemination at an early stage. The failure to improve survival is caused by difficultie...
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ژورنال
عنوان ژورنال: Cancers
سال: 2021
ISSN: 2072-6694
DOI: 10.3390/cancers13051104